Protein Interaction Networks
| | Interactions between proteins within the cell and the associated complexes and networks that these interactions form, underpin the mechanistic basis for much of cellular physiology and function.
Understanding the organization of protein-protein interactions in the context of complexes and networks is therefore essential to the goal of a systems level understanding of life.
We are especially interested in the roles that protein networks play in disease processes and how protein networks are modulated through time and space, and are addressing these problems using both computational and laboratory-based approaches.
Computational Proteomics
Proteomics is a technology for identifying and quantifying proteins in biological samples. An enormous quantity of data is generated from proteomics experiments, requiring computational tools for analysis and interpretation.
Our lab is also involved in developing algorithms and tools that facilitate the analysis of quantitative LC-MS experiments. Projects in this area include development of ProteoMarker (in conjunction with Infochromics) and development of tools for mining protein expression data.
| | Affiliations
We are a new lab (from 2007) based in the Case Center for Proteomics and Bioinformatics in the School of Medicine at Case Western Reserve University. Other affiliations include the Department of Genetics at Case Western Reserve University and Infochromics, a start-up proteomics software company, co-founded by Rob Ewing and based in Toronto, Canada.
|
| Contact
Rob Ewing
Case Center for Proteomics and Bioinformatics
+1.216.368.4380
my.name@case.edu
|
|
|
